Linked Life Data

6227462

Source:http://linkedlifedata.com/resource/pubmed/id/6227462

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-1-27
pubmed:abstractText
The immune response of resistant and susceptible mice infected with Leishmania mexicana has been studied. In resistant mice infection was associated with the development of delayed hypersensitivity to parasite antigens and the development of specific antibodies, and protective immunity to a subsequent challenge infection with L. mexicana was demonstrable. After adoptive transfer of lymph node cells and peritoneal cells from immune donors, recipient mice showed an increased ability to control a challenge infection. T lymphocytes from recovering mice, transferred together with parasite antigens, mediated a specific delayed hypersensitivity. In a local cell-transfer assay, peritoneal cells from immune mice produced significant protection against a living inoculum. Immune serum enhanced the protection conferred by peritoneal cells, but immune serum alone was ineffective. It is postulated that immunity to L. mexicana is mediated by collaboration between T-cell activated macrophages and antibodies. In susceptible BALB/c mice, infection with L. mexicana led to the activation of specific and non-specific suppressor cells. The former are related to T cells whereas the latter belong to the splenic population of adherent cells. Non-specific suppression by these adherent cells was at least partially associated with the release of a suppressor factor that could inhibit the blastogenic response of normal spleen cells activated by mitogens. Both in vitro and in vivo studies suggested the participation of a high parasite load in the induction of non-specific suppressor cells and polyclonal lymphocyte activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-73
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Factors influencing the host response to Leishmania mexicana.
pubmed:publicationType
Journal Article