Linked Life Data

6227379

Source:http://linkedlifedata.com/resource/pubmed/id/6227379

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-1-27
pubmed:abstractText
Previous studies in hyperprolactinaemic women have led to conflicting views about the influence of prolactin (PRL) on serum dehydroepiandrosterone sulphate (DS) levels. This study was designed to examine the effect of a reduction of normal levels of circulating prolactin on the serum DS concentration in twenty ovulating women treated with bromocriptine for 4 months in a double-blind crossover study. The women were recruited after initial studies of hypothalamic-pituitary, gonadal and adrenal function were assessed as being normal. Blood samples were collected in the early follicular and mid-luteal phases of both placebo and bromocriptine treated cycles, and were assayed for LH, FSH, PRL, DS, oestradiol (E2), testosterone (T), androstenedione (A) and sex hormone binding globulin (SHBG). The only significant changes were in serum prolactin which decreased from a mean level of 12.6 (s.e.m. = 0.38) to 9.7 (s.e.m. = 0.36) micrograms/l (P less than 0.0025), and DS which decreased from 4.9 (s.e.m. = 0.23) to 4.5 (s.e.m. = 0.22) mumol/l (P much less than 0.0005) after treatment with bromocriptine. Although the mechanism of this phenomenon is not clear, this study suggests that PRL may have a physiological role in modulating the tonic secretion or metabolism of DS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0725-556X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-25
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Influence of prolactin on serum androgens in normoprolactinaemic women.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study