Linked Life Data

6224214

Source:http://linkedlifedata.com/resource/pubmed/id/6224214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-9-23
pubmed:abstractText
Regulation of the immune response was studied in 22 patients with IgA nephropathy. A significant increase in the IgA production by Pokeweed-stimulated peripheral mononuclear cells maintained in culture for seven days was observed. These patients had significantly less IgA suppressor cell activity, as assessed by the Concanavalin A-generated suppressor cell assay, than the normal controls. The fact that most of the patients studied had increased activity of helper T cells on IgA synthesis, together with an augmentation in the percentage of OKT4+ cells, suggest that the abnormalities in helper T cell function might be the primary defect in this nephropathy. The existence of similar alterations in some of the healthy relatives of the patients further supports a genetic basis for susceptibility to this disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0071-2736
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
642-7
pubmed:dateRevised
2008-2-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Abnormalities of immune regulation in patients with IgA mesangial glomerulonephritis (Berger's disease).
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't