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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-9-23
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pubmed:abstractText |
Immunoregulatory T subsets, defined by monoclonal antibodies, were enumerated in children affected by HBsAg-positive chronic active hepatitis. The helper to suppressor/cytotoxic cells ratio was lower in patients than in age-matched controls. The lower ratio was mainly due to an increase of lymphocytes of the suppressor/cytotoxic phenotype. Helper cells were even fewer in severe chronic hepatitis patients, thereby lowering still further the helper/suppressor ratio. Therapy seemed to influence the ratio in patients affected by moderate active chronic hepatitis, for four of eight children treated with azathioprine and prednisone had a ratio within -1 SD of normal values. The increase of the suppressor/cytotoxic cells in patients affected by chronic hepatitis might be a means for limiting virus-induced cell hyperactivity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0277-2116
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
229-33
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:6223993-Adolescent,
pubmed-meshheading:6223993-Antibodies, Monoclonal,
pubmed-meshheading:6223993-Azathioprine,
pubmed-meshheading:6223993-Child,
pubmed-meshheading:6223993-Child, Preschool,
pubmed-meshheading:6223993-Female,
pubmed-meshheading:6223993-Hepatitis, Chronic,
pubmed-meshheading:6223993-Hepatitis B,
pubmed-meshheading:6223993-Humans,
pubmed-meshheading:6223993-Male,
pubmed-meshheading:6223993-Phenotype,
pubmed-meshheading:6223993-Prednisone,
pubmed-meshheading:6223993-Rosette Formation,
pubmed-meshheading:6223993-T-Lymphocytes,
pubmed-meshheading:6223993-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:6223993-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6223993-T-Lymphocytes, Regulatory
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pubmed:year |
1983
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pubmed:articleTitle |
Immunoregulatory T subsets in chronic active viral hepatitis: characterization by monoclonal antibodies.
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pubmed:publicationType |
Journal Article
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