|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1983-8-26
|
|
pubmed:abstractText |
The effects of neonatal antigen exposure on the adult B cell repertoire have been examined by characterizing the influenza hemagglutinin (HA)-specific response of adult BALB/c mice given antigen soon after birth. Ligand exposure during early life exerts a profound and lasting effect upon the B cell repertoire, characterized by the expansion and preservation of particular antigen-reactive clones and the apparent loss of others. The precise subset of clonotypes selectively preserved depends upon the age at which antigen is first encountered; and is predictable given a knowledge of the emerging primary pool's dynamics and composition. The preserved (secondary) B cells differ from their unprimed precursors with respect to (a) expression of the surface marker detected by the monoclonal antibody J11d, and (b) susceptibility to T cell-mediated suppression. These studies thus demonstrate a strong relationship between the heritable dynamics of the emerging primary B cell repertoire and the effect of ligand-driven events upon repertoire phenotype. In addition, they provide a mechanistic model for certain forms of antigen-induced oligoclonal dominance, especially the phenomenon of original antigenic sin.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-115000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-11993341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-13992961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-301552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-302315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-307588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-309912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-316542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-325170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-383836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-408080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-4133078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-4139234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-4141645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-416167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-4540431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-47889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-47895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-527642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-5922742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-60906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6159417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6159554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-62020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6749528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6766210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6769593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6798155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6804095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6967189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6968812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6974223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6975326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6976990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6982304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-6982918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-7019374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-72780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-75802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-75938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-81853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6223111-93547
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
158
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
112-25
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6223111-Aging,
pubmed-meshheading:6223111-Animals,
pubmed-meshheading:6223111-Animals, Newborn,
pubmed-meshheading:6223111-Antibodies, Monoclonal,
pubmed-meshheading:6223111-Antigens, Viral,
pubmed-meshheading:6223111-B-Lymphocytes,
pubmed-meshheading:6223111-Clone Cells,
pubmed-meshheading:6223111-Hemagglutinins, Viral,
pubmed-meshheading:6223111-Immunization,
pubmed-meshheading:6223111-Influenza A virus,
pubmed-meshheading:6223111-Mice,
pubmed-meshheading:6223111-Mice, Inbred BALB C,
pubmed-meshheading:6223111-Mice, Inbred DBA,
pubmed-meshheading:6223111-T-Lymphocytes, Regulatory
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Restricted adult clonal profiles induced by neonatal immunization. Influence of suppressor T cells.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
