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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1978-3-29
|
| pubmed:abstractText |
Spontaneous and EMS-induced alpha-amanitin-resistant CHO cells have been isolated and characterized. DNA-dependent RNA polymerase II in cell-free extracts from a mutant (ARM-1) was partially resistant to alpha-amanitin. Growing mutants for several generations in the presence or absence of alpha-amanitin did not change the pattern of inhibition. The mutants grew with a lag following transfer to medium with or without alpha-amanitin. The mutants have an altered RNA polymerase II, and possibly an altered cell membrane.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0027-5107
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
65-101
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:622084-Amanitins,
pubmed-meshheading:622084-Cell Line,
pubmed-meshheading:622084-DNA-Directed RNA Polymerases,
pubmed-meshheading:622084-Dose-Response Relationship, Drug,
pubmed-meshheading:622084-Drug Resistance,
pubmed-meshheading:622084-Mutation,
pubmed-meshheading:622084-Phenotype,
pubmed-meshheading:622084-RNA Polymerase II
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
alpha-Amanithin-resistant mutants of Chinese hamster ovary (CHO) cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|