Linked Life Data

6220542

Source:http://linkedlifedata.com/resource/pubmed/id/6220542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Changes in contractility and ATPase activity of SR from hearts of hypothyroid rats were investigated. Rats were made hypothyroid by daily injection of 100 mg/kg methimazole for 14 days. In methimazole-treated rats, the contractile force, the maximum velocity of tension development and relaxation were significantly decreased, however, the time to peak tension remained unchanged. Function of SR was studied by determining of Ca2+-activated ATPase activity, which was significantly decreased after methimazole treatment. This diminution may be partially responsible for a slower reduction of the free Ca2+ in the surroundings of contractile proteins and thus decrease the rate of relaxation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5288
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The effect of hypothyroidism on myocardial contractility and sarcoplasmic reticulum function in rats.
pubmed:publicationType
Journal Article