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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1978-3-21
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pubmed:abstractText |
A double-antibody radioimmunoassay was used to determine the concentration and distribution of apolipoprotein A-I (apoA-I) in the plasma of patients with Tangier disease. Obligate heterozygotes for Tangier disease had apoA-I levels that were 50% or less of controls, even when estimates of high-density lipoprotein cholesterol concentration were normal. Plasma apoA-I levels in Tangier homozygotes were at most 3% of normal. Most of the apoA-I in the plasma of homozygotes sedimented in the ultracentrifuge at density 1.21 g/ml, and no more than 20% was recovered in the plasma lipoprotein fraction. Radioimmunoassay demonstrated no immunochemical differences between Tangier and control apoA-I.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0026-0495
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:622047-Adult,
pubmed-meshheading:622047-Apolipoproteins,
pubmed-meshheading:622047-Child,
pubmed-meshheading:622047-Child, Preschool,
pubmed-meshheading:622047-Female,
pubmed-meshheading:622047-Heterozygote,
pubmed-meshheading:622047-Homozygote,
pubmed-meshheading:622047-Humans,
pubmed-meshheading:622047-Hypolipoproteinemias,
pubmed-meshheading:622047-Lipids,
pubmed-meshheading:622047-Male,
pubmed-meshheading:622047-Middle Aged,
pubmed-meshheading:622047-Radioimmunoassay,
pubmed-meshheading:622047-Tangier Disease
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pubmed:year |
1978
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pubmed:articleTitle |
Abnormal concentration and anomalous distribution of apolipoprotein A-I in Tangier disease.
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pubmed:publicationType |
Journal Article
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