Linked Life Data

6220331

Source:http://linkedlifedata.com/resource/pubmed/id/6220331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1983-5-27
pubmed:abstractText
The effects of ischaemia on nervous tissue and cerebral capillary vessel ultrastructure and their prevention by Duxil were studied in rabbits. Ischaemia induced by bilateral occlusion of the carotid arteries induced minor changes in the endothelium of some capillary vessels: irregularities in the luminal surface with subsequent increase in the number of caveolae, increase in the number and size of membrane microvillosities and bullae, and retraction of the nuclei. Ischaemia acted mainly on astrocyte processes and perikarion which became shollen with altered mitochondria and complete absence of glycogen. The neurons remained normal but seemed to contain slightly more lysosomes. After administration of Duxil 10 min before ischaemia was induced, there were no endothelial changes; the astrocytes were less swollen and above all, their glycogen content was preserved; there seemed to be less lysosomes in the neurons. The effects of Duxil on cell oxygenation and oxidative metabolism may account for its protective action on endothelial, glial and neural cells.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
830-8
pubmed:dateRevised
2009-10-8
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Ultrastructural study of acute ischemia at the cerebral level. Effects of 5023 SE].
pubmed:publicationType
Journal Article, English Abstract