Linked Life Data

6220147

Source:http://linkedlifedata.com/resource/pubmed/id/6220147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-5-27
pubmed:abstractText
The gonads of the fetal horse were found to be relatively devoid of 3 beta-hydroxysteroid dehydrogenase and other enzymes which metabolize dehydroepiandrosterone (DHA). In short-term in-vitro incubation experiments fetal liver converted DHA to the potential equilin precursor, 7 alpha-hydroxy DHA. DHA was converted to oestrone when incubated with extracts of horse placenta but 7 alpha-hydroxy DHA was not converted to equilin. Levels of DHA measured in peripheral blood of mares throughout pregnancy paralleled those of equilin and oestrone, and DHA concentrations fell rapidly after fetal gonadectomy, as did those of equilin and oestrone. Administration of [4-(14)C]-DHA and [7-3H]DHA to the fetus resulted in the incorporation of both 14C and 3H into maternal urinary oestrone but neither isotope was present in urinary equilin. These findings confirm the role of fetal DHA as a precursor of oestrone, but do not support the previously suggested role of the fetal liver in the synthesis of equilin. They are, however, compatible with the hypothesis that equilin is formed via a pathway which diverges from the terpenoid steroid synthetic route before DHA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0449-3087
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-97
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Dehydroepiandrosterone synthesis by the fetal foal and its importance as an oestrogen precursor.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't