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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1983-5-27
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pubmed:abstractText |
Lymphocyte profiles of untreated diabetes-prone BB rats (BBDP) and their normal marrow-inoculated tolerant littermates were determined with the aid of a fluorescence-activated cell sorter by using monoclonal antibodies specific for rat T cell (W3/13) and T cell subsets (W3/25, T helper; OX8, T cytotoxic/suppressor). In contrast to non-diabetes-prone rats and to their marrow-inoculated littermates, untreated BBDP rats were found to be T lymphocytopenic with reduced W3/25+ cells and with a major loss of OX8+ cells. Moreover, their lymphocytes displayed depressed alloreactivity that was not restored by addition of exogenous IL 2.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2168-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6220083-Animals,
pubmed-meshheading:6220083-Antibodies, Monoclonal,
pubmed-meshheading:6220083-Bone Marrow Transplantation,
pubmed-meshheading:6220083-Diabetes Mellitus, Experimental,
pubmed-meshheading:6220083-Female,
pubmed-meshheading:6220083-Immune Tolerance,
pubmed-meshheading:6220083-Interleukin-2,
pubmed-meshheading:6220083-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6220083-Male,
pubmed-meshheading:6220083-Phenotype,
pubmed-meshheading:6220083-Rats,
pubmed-meshheading:6220083-Rats, Inbred ACI,
pubmed-meshheading:6220083-Rats, Inbred BN,
pubmed-meshheading:6220083-Rats, Inbred Lew,
pubmed-meshheading:6220083-Rats, Inbred Strains,
pubmed-meshheading:6220083-Rats, Inbred WF,
pubmed-meshheading:6220083-T-Lymphocytes,
pubmed-meshheading:6220083-Thoracic Duct
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pubmed:year |
1983
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pubmed:articleTitle |
Analytical and functional studies on the T cells of untreated and immunologically tolerant diabetes-prone BB rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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