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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
Copper and manganese superoxide dismutases (Cu-SOD and Mn-SOD) were measured by radioimmunoassay in B and T lymphocytes and macrophages, in patients with trisomy 21 and in matched controls. In the controls, Cu-SOD was present in greater amounts than Mn-SOD and there were quantitative differences in the distribution in the three cellular sub-populations. In trisomy 21, levels of Cu-SOD were raised, with no change in levels of Mn-SOD, supporting the theory of a gene dosage effect. There were significant positive and negative correlations between age and Cu-SOD levels in controls, and a correlation approaching significance for Mn-SOD. In trisomy 21, there was no correlation between age and Cu-SOD levels, and the only significant correlation for Mn-SOD was for B lymphocytes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
895-902
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6219263-Adolescent,
pubmed-meshheading:6219263-Adult,
pubmed-meshheading:6219263-Age Factors,
pubmed-meshheading:6219263-B-Lymphocytes,
pubmed-meshheading:6219263-Cell Separation,
pubmed-meshheading:6219263-Child,
pubmed-meshheading:6219263-Child, Preschool,
pubmed-meshheading:6219263-Copper,
pubmed-meshheading:6219263-Down Syndrome,
pubmed-meshheading:6219263-Female,
pubmed-meshheading:6219263-Humans,
pubmed-meshheading:6219263-Macrophages,
pubmed-meshheading:6219263-Male,
pubmed-meshheading:6219263-Manganese,
pubmed-meshheading:6219263-Superoxide Dismutase,
pubmed-meshheading:6219263-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Immunoreactive Cu-SOD and Mn-SOD in lymphocytes sub-populations from normal and trisomy 21 subjects according to age.
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pubmed:publicationType |
Journal Article
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