Linked Life Data

6218347

Source:http://linkedlifedata.com/resource/pubmed/id/6218347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-3-11
pubmed:abstractText
In 32 patients with B-cell chronic lymphatic leukaemia (CLL), OKT8+ suppressor T cells were increased in relative (mean 54 +/- 14%; normal mean 34 +/- 6%) and absolute (1.8 +/- 1.6 X 10(9)/1; normal range 0.3-0.6 X 10(9)/1) numbers. OKT4+ helper cells were reduced in relative (mean 53 +/- 15%; normal mean 65 +/- 7%) but not absolute (1.7 +/- 1.4 X 10(9)/1; normal range 0.6-1.4 X 10(9)/1) numbers. Essentially identical results were obtained in treated and untreated patients. There was no significant association between T-cell subset numbers and clinical stage, whether assessed by the Rai classification or the more recent Binet system, although the OKT4+/8+ ratio was slightly lower in advanced disease. The study suggests that the immunoparesis so characteristic of CLL may be attributable to increased suppressor T-cell activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-2126
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
653-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Suppressor T cells in B-cell chronic lymphocytic leukaemia: relationship to clinical stage.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't