Linked Life Data

6218112

Source:http://linkedlifedata.com/resource/pubmed/id/6218112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-3-17
pubmed:abstractText
Mezlocillin was administered as an intravenous bolus injection to eight children, aged 4-15, requiring antibiotic therapy; the dose was either 75 mg/kg or 37.5 mg/kg. All of the patients had advanced renal insufficiency. Five of the children required chronic intermittent hemodialysis. The microbiological method of Grove and Randall was used for the quantitative determination of mezlocillin in the serum. Ten minutes after the injection, the concentration of mezlocillin in the serum was approximately 90 mg/l and 40 mg/l, respectively. The determinations 30 and 60 minutes after the injection showed that the mezlocillin concentrations had fallen rapidly to approximately 30 mg/l and 20 mg/l, respectively. The mezlocillin concentrations were still approximately 2 mg/l and 1 mg/l, respectively, 12 hours after administration. For the period between 10 and 60 minutes, the half-lives were between 33 and 57 minutes. In general, we can conclude that a single bolus injection of 75 mg/kg will result in mezlocillin concentrations in the serum of uremic children which allow us to expect good antibacterial efficacy, at least for the first few hours following the injection. On the basis of our studies, half the dosage does not appear to be sufficient.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8126
pubmed:author
pubmed:issnType
Print
pubmed:volume
10 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S196-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Mezlocillin concentrations in the serum of children with impaired renal function].
pubmed:publicationType
Journal Article, English Abstract