Linked Life Data

6218069

Source:http://linkedlifedata.com/resource/pubmed/id/6218069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-3-11
pubmed:abstractText
The results discussed in this review show that the TNP-specific IgA lambda 2-secreting BALB/c plasmacytoma MOPC-315 is partially composed of small lymphocytoid, presecretory cells which express the Lyb3 determinant. It is shown that MOPC-315 cell secretory differentiation, but not clonal proliferation, can be modulated by anti-Lyb3. Anti-Lyb3 serum has been shown to: 1) augment secretory differentiation enhancement by suboptimal numbers of secretory differentiation-enhancing, IgA315-specific helper T cells; 2) replace this secretory differentiation-enhancing T cell population as long as clone growth helper T cells are present; and 3) block suppression of secretory differentiation mediated by carrier-immune Ts cells. These results demonstrate that whether anti-Lyb3 serum enhances immune responses by replacing or augmenting a helper signal or by counteracting suppressor signals, the effects are focused on secretory differentiation events and have no effect on clonal proliferation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0105-2896
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Lyb3: a B cell surface antigen associated with triggering secretory differentiation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.