Linked Life Data

6216328

Source:http://linkedlifedata.com/resource/pubmed/id/6216328

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-1-7
pubmed:abstractText
A study with freeze-fracture electron microscopy was made on erythrocyte membrane in 5 patients with the hereditary neurological disease with chorea, areflexia, and acanthocytosis (Levine et al. 1968). Fixed or unfixed specimens from circulating blood were processed by the freeze-fracture technique, and the distribution of the intramembranous particles was studied. A significant increase in areas without intramembraneous particles (IMP-free areas) was found in all cases with the disease as compared to normal subjects. The group mean value of IMP-free areas was 0.11 +/- 0.01 X 10-2 micrometer2/micrometer2 fracture face in the normal P face and 0.10 +/- 0.04 in the normal E face, compared with 1.77 +/- 0.49 in the P face and 1.33 +/- 0.17 in the E face in material from patients. Although abnormalities in lipid metabolism or membrane properties of erythrocytes have not been revealed in this condition hitherto, the present data suggest an abnormality of membrane fluidity due to abnormal lipid metabolism in this unique disease with neurological disorders and acanthocytosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-97
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Morphological abnormalities of erythrocyte membrane in the hereditary neurological disease with chorea, areflexia and acanthocytosis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't