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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-1-27
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pubmed:abstractText |
In this paper we have examined the effects of i.v. administered monoclonal anti-I-J antibodies on tumor growth in syngeneic and semi-syngeneic hosts. These antibodies inhibit tumor growth in mice bearing the appropriate I-J-encoded gene product on their lymphoid cells at nanogram dosages. The spleens of monoclonal anti-I-J-treated primary tumor-bearing mice do not contain transferable tumor-specific cells. These findings suggest that inhibition of suppressor cell function may be the mechanism by which anti-I-J antibodies inhibit tumor growth. We have also demonstrated that tumors growing in F1 hybrid mice are inhibited by monoclonal anti-I-J antibodies reactive with either parental haplotype and that there is no evidence of synergy when both antibodies are administered simultaneously. This may indicate that I-J molecules are codominantly expressed on a critical component of the F1 suppressor pathway.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6216287-Animals,
pubmed-meshheading:6216287-Antibodies, Monoclonal,
pubmed-meshheading:6216287-Guinea Pigs,
pubmed-meshheading:6216287-Immune Tolerance,
pubmed-meshheading:6216287-Isoantibodies,
pubmed-meshheading:6216287-Major Histocompatibility Complex,
pubmed-meshheading:6216287-Neoplasms, Experimental,
pubmed-meshheading:6216287-T-Lymphocytes, Regulatory
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pubmed:year |
1983
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pubmed:articleTitle |
Inhibition of tumor growth by monoclonal anti-I-J antibodies.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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