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rdf:type |
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lifeskim:mentions |
umls-concept:C0003315,
umls-concept:C0007600,
umls-concept:C0024264,
umls-concept:C0086418,
umls-concept:C0205419,
umls-concept:C0205430,
umls-concept:C0871261,
umls-concept:C1514873,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1983-1-19
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pubmed:abstractText |
Human leukaemia and lymphoma cell lines were investigated as stimulating cells in an allogeneic mixed lymphocyte response. Purified T cells and unfractionated mononuclear cells from normal donors were used as responders. The cell lines fell into three groups: (i) those which stimulated allogeneic responder T cells in the presence or absence of accessory (non-T) cells; (ii) those which stimulated T cells only in the presence of accessory cells; and (iii) those which failed to stimulate in either case. The accessory function was provided by adherent cells and non-adherent, non-T cells. There was no correlation between the stimulatory capacity of these cell lines and the presence of serologically defined HLA-DR determinants. These results are discussed in the context of the current two-signal hypothesis for T-cell activation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-1084895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-112038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-144773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-149362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-156581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-158051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-159311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-163658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-206705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-303772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-315070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-317476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-4100582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-4276467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6162776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6165093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6168583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6170720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-61995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6245297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6444277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6447826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6451045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6454727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6455191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6460832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6809376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6931961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6966303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6968601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6973402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6975346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-6987781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-7000674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6216200-95026
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-2805
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6216200-Adult,
pubmed-meshheading:6216200-Cell Line,
pubmed-meshheading:6216200-HLA-DR Antigens,
pubmed-meshheading:6216200-Histocompatibility Antigens Class II,
pubmed-meshheading:6216200-Humans,
pubmed-meshheading:6216200-Indomethacin,
pubmed-meshheading:6216200-Leukemia,
pubmed-meshheading:6216200-Lymphocyte Activation,
pubmed-meshheading:6216200-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6216200-Lymphocytes,
pubmed-meshheading:6216200-Lymphoma,
pubmed-meshheading:6216200-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
Variation in accessory cell requirements in human mixed lymphocyte response to leukaemic cell lines.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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