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rdf:type |
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lifeskim:mentions |
umls-concept:C0018792,
umls-concept:C0020564,
umls-concept:C0022173,
umls-concept:C0086418,
umls-concept:C0871261,
umls-concept:C0949657,
umls-concept:C1704632,
umls-concept:C1705165,
umls-concept:C1706817,
umls-concept:C2700061,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1982-12-2
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pubmed:abstractText |
1. The light-chain subunits of human atrial and ventricular cardiac muscle were examined by two-dimensional polyacrylamide-gel electrophoresis and limited proteolytic digestion. The light-chain patterns in the normal right and left atria were identical. 2. Myosin preparations isolated from right or left atria that had been subjected to cardiac-pressure-overload-induced hypertrophy also contained ventricular light-chain subunits. These were identified by peptide mapping in sodium dodecyl sulphate. 3. Ventricular light chain-2 was the major species in hypertrophied atria, although light chain-1 subsequently appeared in severe pressure-overload-hypertrophied cases. Evidence is presented for the existence of more than one form of ventricular light chain-2. 4. The transition from atrial to ventricular myosin light chains correlated with the degree of pressure-overload hypertrophy in 83 examples of surgically excised atria. 5. The adult atrial light chain-1 was shown to be homologous to the human foetal ventricular light chain-1 [Price, Littler & Cummins (1980) Biochem. J. 191, 571-580] by peptide mapping. 6. A scheme of atrial/ventricular myosin light-chain isoenzyme transitions is discussed in relation to changing contractile properties in cardiac muscle, together with implications for the role of light-chain subunits.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-1212218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-123179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-124376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-13860702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-143279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-158969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-212314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-22048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-236308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-320200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-338537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-38914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-4252498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-460404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6119311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6452207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6452895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6453716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6454850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6457646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-6772970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-7196501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-722801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-7236212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-7317029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-7319048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-745235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-761639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6215032-91973
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
205
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-204
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:6215032-Blood Pressure,
pubmed-meshheading:6215032-Cardiomegaly,
pubmed-meshheading:6215032-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:6215032-Heart Atria,
pubmed-meshheading:6215032-Heart Ventricles,
pubmed-meshheading:6215032-Humans,
pubmed-meshheading:6215032-Isoelectric Focusing,
pubmed-meshheading:6215032-Isoenzymes,
pubmed-meshheading:6215032-Myocardium,
pubmed-meshheading:6215032-Myosins,
pubmed-meshheading:6215032-Peptide Fragments
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pubmed:year |
1982
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pubmed:articleTitle |
Transitions in human atrial and ventricular myosin light-chain isoenzymes in response to cardiac-pressure-overload-induced hypertrophy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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