|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1978-3-29
|
|
pubmed:abstractText |
The steady-state slope conductance of Limulus ventral photoreceptors increases markedly when the membrane is depolarized from rest. The ionic basis of this rectification has been examined with a voltage-clamp technique. Tail currents that occur when membrane potential is repolarized after having been depolarized have been identified. The tail currents reverse direction at a voltage that becomes more positive when Ko is increased. Rectification is reduced by extracellular 4-aminopyridine and by intracellular injection of tetra-ethyl-ammonium (TEA). These results indicate that the membrane rectification around resting potential is due primarily to voltage-sensitive K+ channels. The increase in gK caused by depolarization is not mediated by a voltage-dependent rise in in Cai++, since intracellular injection of Ca++ causes a decrease rather than an increase in slope conductance. TEA can be used to examine the functional role of the K+ channels because it blocks them without substantially affecting the light-activated Na+ conductance. The effect of TEA on response-intensity curves shows that the K+ channels serve to compress the voltage range of receptor potentials.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-1114339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-1177091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-1181378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-1244890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-13320339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-14225259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-14324992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-14946713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-4112955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-4155426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-4295072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-4449052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-4673460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-4817353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5025746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5044059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5122373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5219492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5683052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5806592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-5806593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-810540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-950599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/621492-994042
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-1295
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
71
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
101-20
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:621492-Animals,
pubmed-meshheading:621492-Calcium,
pubmed-meshheading:621492-Cell Membrane,
pubmed-meshheading:621492-Horseshoe Crabs,
pubmed-meshheading:621492-Membrane Potentials,
pubmed-meshheading:621492-Models, Biological,
pubmed-meshheading:621492-Osmolar Concentration,
pubmed-meshheading:621492-Photoreceptor Cells,
pubmed-meshheading:621492-Potassium,
pubmed-meshheading:621492-Pyridines,
pubmed-meshheading:621492-Tetraethylammonium Compounds
|
|
pubmed:year |
1978
|
|
pubmed:articleTitle |
Voltage-sensitive potassium channels in Limulus ventral photoreceptors.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
