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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1982-10-21
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pubmed:abstractText |
Serum vitamin E concentrations were measured in 47 severely handicapped patients, aged from 4 to 23 years, and in 22 controls. Thirty-three of the handicapped patients with seizures were treated with phenytoin and phenobarbital; the remaining 14 patients were not treated. The serum vitamin E levels were lower in the handicapped than in controls. Among the handicapped, those treated with anticonvulsants showed much lower levels of serum vitamin E than those untreated. Ten patients under anticonvulsant therapy were selected to receive d-1-alpha tocopherol acetate, 100 mg/day, based on their low serum vitamin E levels (range of 0.27 to 0.61 mg/100 ml). After one month of tocopherol treatment, both their serum vitamin E levels and hemolysis tests returned to normal. During a three-month tocopherol treatment period, both the frequencies of seizure attacks and the electroencephalogram (EEG) patterns remained unchanged. Supplementation with vitamin E is recommended in some patients under anticonvulsant therapy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0270-322X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6213919-Adolescent,
pubmed-meshheading:6213919-Adult,
pubmed-meshheading:6213919-Anticonvulsants,
pubmed-meshheading:6213919-Child,
pubmed-meshheading:6213919-Child, Preschool,
pubmed-meshheading:6213919-Disabled Persons,
pubmed-meshheading:6213919-Electroencephalography,
pubmed-meshheading:6213919-Humans,
pubmed-meshheading:6213919-Seizures,
pubmed-meshheading:6213919-Time Factors,
pubmed-meshheading:6213919-Vitamin E,
pubmed-meshheading:6213919-Vitamin E Deficiency
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pubmed:year |
1980
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pubmed:articleTitle |
Serum vitamin E concentration in patients with severe multiple handicaps treated with anticonvulsants.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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