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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1982-9-10
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pubmed:abstractText |
Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigen-Antibody Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Complement Activating Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C1q,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Mercuric Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Mercury,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2972
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6212254-Animals,
pubmed-meshheading:6212254-Antigen-Antibody Complex,
pubmed-meshheading:6212254-Autoantibodies,
pubmed-meshheading:6212254-Autoimmune Diseases,
pubmed-meshheading:6212254-Basement Membrane,
pubmed-meshheading:6212254-Complement Activating Enzymes,
pubmed-meshheading:6212254-Complement C1q,
pubmed-meshheading:6212254-Complement System Proteins,
pubmed-meshheading:6212254-Female,
pubmed-meshheading:6212254-Glycoproteins,
pubmed-meshheading:6212254-Immunoglobulin G,
pubmed-meshheading:6212254-Kidney Glomerulus,
pubmed-meshheading:6212254-Laminin,
pubmed-meshheading:6212254-Male,
pubmed-meshheading:6212254-Mercuric Chloride,
pubmed-meshheading:6212254-Mercury,
pubmed-meshheading:6212254-Rats,
pubmed-meshheading:6212254-Rats, Inbred BN,
pubmed-meshheading:6212254-Receptors, Complement,
pubmed-meshheading:6212254-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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