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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1982-8-14
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pubmed:abstractText |
Six candidate irreversible inhibitors of uridine--deoxyuridine phosphorylase (EC 2.4.2.3) from Walker 256 rat tumor were synthesized. These compounds connect a terminal sulfonyl fluoride group to the 1-benzyl moiety of 1-benzyl-5-(3-ethoxybenzyl)uracil (9). Although none of the compounds were irreversible inhibitors, the four 3-[(fluorosulfonyl)benzamido] analogues (14-17) of 9 were good reversible inhibitors of the enzyme which were complexed from 125- to 360-fold better than the substrate, 5-fluoro-2'-deoxyuridine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
600-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6211547-Animals,
pubmed-meshheading:6211547-Antineoplastic Agents,
pubmed-meshheading:6211547-Binding Sites,
pubmed-meshheading:6211547-Carcinoma 256, Walker,
pubmed-meshheading:6211547-Chemical Phenomena,
pubmed-meshheading:6211547-Chemistry,
pubmed-meshheading:6211547-Floxuridine,
pubmed-meshheading:6211547-Pentosyltransferases,
pubmed-meshheading:6211547-Rats,
pubmed-meshheading:6211547-Uracil,
pubmed-meshheading:6211547-Uridine Phosphorylase
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pubmed:year |
1982
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pubmed:articleTitle |
Irreversible enzyme inhibitors. 202. Candidate active-site-directed irreversible inhibitors of 5-fluoro-2'-deoxyuridine phosphorylase from Walker 256 rat tumor derived from 1-benzyl-5-(3-ethoxybenzyl)uracil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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