Linked Life Data

6211106

Source:http://linkedlifedata.com/resource/pubmed/id/6211106

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
1982-7-22
pubmed:abstractText
Studies were initiated to determine whether or not transformation of lymphocytes isolated from individuals functionally immune to malaria would be a useful tool for the identification of protective antigens derived from continuous cultures of Plasmodium falciparum. Soluble antigen preparations stimulated lymphoproliferative responses in cells isolated from immune and nonimmune individuals. To rule out the possibility that those nonspecific responses were mixed lymphocyte reactions or other, undefined stimuli due to the heterologous nature of the lymphocyte culture system, subsequent experiments were conducted using extracts from parasites cultured in erythrocytes obtained from the same donors whose lymphocytes were tested. Soluble parasite extracts from continuously cultured P. falciparum produce nonspecific lymphocyte blast transformation responses in immunologically naive individuals. Such mitogens should be identified and removed from antigen preparations before a vaccine against malaria can be developed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Mitogenic activity of extracts from continuous cultures of Plasmodium falciparum.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't