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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-2-11
|
| pubmed:abstractText |
Capsaicin (15 or 100 mg/kg, s.c.) produced thermal analgesia in the rat hot plate test (55 degrees C). Capsaicin (100 mg/kg) also caused a reduction in spinal cord substance P levels. However, the time-course of capsaicin-induced depletion of substance P levels does not correlate with the time-course of thermal analgesia. Also, substance P depletion is biphasic, suggesting that more than one mechanism is involved in capsaicin's ability to reduce substance P levels in the spinal cord.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
322
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
305-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:6210131-Animals,
pubmed-meshheading:6210131-Capsaicin,
pubmed-meshheading:6210131-Hot Temperature,
pubmed-meshheading:6210131-Male,
pubmed-meshheading:6210131-Pain,
pubmed-meshheading:6210131-Rats,
pubmed-meshheading:6210131-Rats, Inbred Strains,
pubmed-meshheading:6210131-Sensory Thresholds,
pubmed-meshheading:6210131-Spinal Cord,
pubmed-meshheading:6210131-Substance P
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Biphasic time-course of capsaicin-induced substance P depletion: failure to correlate with thermal analgesia in the rat.
|
| pubmed:publicationType |
Journal Article
|