Linked Life Data

6208680

Source:http://linkedlifedata.com/resource/pubmed/id/6208680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-11-23
pubmed:abstractText
Monoclonal antibodies were used to compare the antigenicities of the haemagglutinins of two receptor binding mutants of X-31 (H3N2) influenza virus. The mutants which differed from each other in recognizing sialic acid in either alpha 2-6 linkage or alpha 2-3 linkage to galactose also differed exclusively at residue 226 of the HA1 polypeptides of their haemagglutinins (G. N. Rogers, J. C. Paulson, R. S. Daniels, J. J. Skehel, I. A. Wilson, and D. C. Wiley, Nature (London) 304, 76-78, 1983). The results obtained indicate that whereas the majority of antihaemagglutinin monoclonal antibodies react with both mutants equally well, a number which specifically recognize residues 193, 199, 219, and 229 of HA1 of the alpha 2-6 linkage-binding mutant fail to recognize the alpha 2-3 linkage-binding haemagglutinins. The results are discussed with reference to the three-dimensional structure of the haemagglutinin and in relation to differences in antigenicity observed in the haemagglutinins of viruses grown in cells of different types.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
174-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Antigenic analyses of influenza virus haemagglutinins with different receptor-binding specificities.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't