Linked Life Data

6208035

Source:http://linkedlifedata.com/resource/pubmed/id/6208035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1984-12-17
pubmed:abstractText
Cloned, Lyt-1+,2-, antigen-specific, Ia-restricted T cell lines can inhibit the growth of Ia-bearing B lymphoma cells in the presence of specific antigen. This effect is due to cytolysis of the B lymphoma cells in an antigen-specific, Ia-restricted manner by the cloned T cell lines. These cloned T cell lines can also kill lipopolysaccharide-activated normal B cells, while they activate resting B cells to divide and secrete immunoglobulin and are thus helper T cells as well as cytolytic T cells. The mechanism of cytolysis was examined in detail. Killing was mediated by a nonspecific mechanism after specific stimulation of the T cells with antigen presented in the context of the appropriate Ia glycoprotein complex, possibly implying a role for a soluble mediator. This simple system involving two clonal populations allows a detailed analysis of T-B interactions. Our studies are consistent with the view that both cognate and noncognate interactions of Ia-restricted T cells with B cells are mediated by nonspecific factors. Thus, the difference between interactions that appear to be cognate and those that appear to be noncognate may be quantitative rather than qualitative. That two cloned populations of cells can show either pattern of interaction depending on T-B ratio provides strong support for this view. Finally, that cloned helper T cells can kill activated B cells in an antigen-specific fashion may provide a new mechanism of immune regulation that would be especially important in responses to self antigens in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
878-86
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't