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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1984-10-24
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pubmed:abstractText |
Starvation of 300 g rats for 3 days decreased ventricular-muscle total protein content and total RNA content by 15 and 22% respectively. Loss of body weight was about 15%. In glucose-perfused working rat hearts in vitro, 3 days of starvation inhibited rates of protein synthesis in ventricles by about 40-50% compared with fed controls. Although the RNA/protein ratio was decreased by about 10%, the major effect of starvation was to decrease the efficiency of protein synthesis (rate of protein synthesis relative to RNA). Insulin stimulated protein synthesis in ventricles of perfused hearts from fed rats by increasing the efficiency of protein synthesis. In vivo, protein-synthesis rates and efficiencies in ventricles from 3-day-starved rats were decreased by about 40% compared with fed controls. Protein-synthesis rates and efficiencies in ventricles from fed rats in vivo were similar to values in vitro when insulin was present in perfusates. In vivo, starvation increased the rate of protein degradation, but decreased it in the glucose-perfused heart in vitro. This contradiction can be rationalized when the effects of insulin are considered. Rates of protein degradation are similar in hearts of fed animals in vivo and in glucose/insulin-perfused hearts. Degradation rates are similar in hearts of starved animals in vivo and in hearts perfused with glucose alone. We conclude that the rates of protein turnover in the anterogradely perfused rat heart in vitro closely approximate to the rates in vivo in absolute terms, and that the effects of starvation in vivo are mirrored in vitro.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-1112824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-14420491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-14420493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-151150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-444219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-4817404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-4909224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-534531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-5542013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6158872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6189483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6193782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6193783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6199013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-624716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6342616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6346895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6347182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6712594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6756391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6756392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6786283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-686162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6987007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-6994712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-7326016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-7354382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-811266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6206849-961895
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
222
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
395-400
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6206849-Animals,
pubmed-meshheading:6206849-Heart,
pubmed-meshheading:6206849-Heart Ventricles,
pubmed-meshheading:6206849-Insulin,
pubmed-meshheading:6206849-Male,
pubmed-meshheading:6206849-Muscle Proteins,
pubmed-meshheading:6206849-Myocardium,
pubmed-meshheading:6206849-Organ Size,
pubmed-meshheading:6206849-RNA,
pubmed-meshheading:6206849-Rats,
pubmed-meshheading:6206849-Rats, Inbred Strains,
pubmed-meshheading:6206849-Starvation
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pubmed:year |
1984
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pubmed:articleTitle |
Rates of protein turnover in vivo and in vitro in ventricular muscle of hearts from fed and starved rats.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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