| pubmed-article:6205987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C1979844 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C1979845 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C0332298 | lld:lifeskim |
| pubmed-article:6205987 | lifeskim:mentions | umls-concept:C1517050 | lld:lifeskim |
| pubmed-article:6205987 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6205987 | pubmed:dateCreated | 1984-10-2 | lld:pubmed |
| pubmed-article:6205987 | pubmed:abstractText | We have shown that cytotoxic T lymphocytes (CTL) raised in H-2d mice use H-2Ld but not H-2Dd or H-2Kd antigens as restricting elements in lymphocytic choriomeningitis virus (LCMV) and vesicular stomatis virus (VSV) infections. To localize the regions of H-2Ld protein recognized by CTL, we constructed a recombinant H-2Ld/Dd gene encoding a hybrid antigen with alpha 1 and alpha 2 external domains of H-2Ld and alpha 3, transmembrane and cytoplasmic domains of H-2Dd. The recombinant gene was transfected into mouse cells and the hybrid molecules were characterized serologically, biochemically and functionally. In all assays, H-2Ld/Dd molecules were recognized by LCMV-and VSV-specific H-2Ld-restricted CTL in a manner similar to that of wild-type H-2Ld antigens. Analogous results were obtained with alloreactive CTL. Hybrid antigens containing the alpha 3 domain of H-2Ld fused to alpha 1 and alpha 2 domains of a Qa-2,3 region-encoded antigen were not used as restricting elements by LCMV-specific CTL. These results suggest that H-2Ld-restricted CTL directed against LCMV and VSV recognize determinants controlled by the alpha 1 and/or alpha 2 domains of the H-2Ld molecule. | lld:pubmed |
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| pubmed-article:6205987 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6205987 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6205987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6205987 | pubmed:issn | 0093-7711 | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:FormanJJ | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:HoodLL | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:GoodenowR SRS | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:OrrEE | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:McMillanMM | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:BraytonP RPR | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:StroynowskiII | lld:pubmed |
| pubmed-article:6205987 | pubmed:author | pubmed-author:FrelingerJJ | lld:pubmed |
| pubmed-article:6205987 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6205987 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:6205987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6205987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6205987 | pubmed:pagination | 141-54 | lld:pubmed |
| pubmed-article:6205987 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6205987 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6205987 | pubmed:articleTitle | Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by alpha 1 and alpha 2 but not alpha 3 external domains. | lld:pubmed |
| pubmed-article:6205987 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6205987 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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