Linked Life Data

6205826

Source:http://linkedlifedata.com/resource/pubmed/id/6205826

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-9-26
pubmed:abstractText
A search for genes located on human chromosome 21 resulted in the isolation of a HeLa cDNA clone, pUNC724, which hybridized to 3.7 and 2.5 kilobase (kb) EcoRI fragments on each of the human acrocentric chromosomes. In situ hybridization further localized pUNC724 to the pericentromeric region of the human acrocentrics. Two other EcoRI fragments that hybridized to pUNC724 were assigned to the long arms of chromosomes 1 and 18. The pUNC724 sequence does not appear to be related to ribosomal or satellite DNA sequences. The juxtaposition of DNA sequences homologous to pUNC724 and ribosomal DNA sequences presumably occurred within the past thirty-five million years, following the divergence of the lines leading to man and the New World owl monkey, Aotus trivirgatus--pUNC724 is not syntenic with the single chromosome containing ribosomal DNA sequences in the owl monkey.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0171
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-105
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Recent evolution of DNA sequence homology in the pericentromeric regions of human acrocentric chromosomes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't