Linked Life Data

6205277

Source:http://linkedlifedata.com/resource/pubmed/id/6205277

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5975
pubmed:dateCreated
1984-8-30
pubmed:abstractText
Retroviruses isolated from avian, feline, murine and simian sources have been found to be inactivated and lysed by normal human serum. There is much evidence that complement is activated directly by retroviruses in the absence of antibody. Thus, human complement is thought to function as a natural defence mechanism against horizontal infection by retroviruses. Recently, a novel retrovirus, human T-cell leukaemia virus (HTLV), has been shown to be associated with adult T-cell leukaemia/lymphoma (ATL). A large number of healthy adults in south-west Japan, the West Indies and Africa carry antibodies against HTLV and these seropositive individuals are considered to be carriers of HTLV. Thus, horizontal spread of HTLV occurs frequently among humans. We set out to determine whether HTLV reacts with human complement, and report here that, unlike other animal retroviruses, HTLV is not lysed by normal human serum--this might explain the infectivity and persistence of HTLV in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
310
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
324-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Human T-cell leukaemia virus is not lysed by human serum.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't