|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1984-9-18
|
|
pubmed:abstractText |
A cloned effector-type suppressor T cell line, 3D10, which is known to suppress the antibody response against dinitrophenylated keyhole limpet hemocyanin (KLH), produced a soluble KLH-specific factor (TsF) that can replace the function of parental T cell clones. High activity of TsF was released spontaneously into the culture supernatant when cultured in interleukin 2 (IL 2)-containing medium, requiring no antigenic stimulation. The culture supernatant of 3D10 was also capable of inhibiting the KLH-induced proliferative response of primed T cells in an antigen-specific manner. The direct target of TsF was found to be Lyt-1+2- T cells undergoing an early stage of antigen-specific proliferation. TsF was antigen binding but lacked any other serologic markers such as I-J and immunoglobulin heavy chain-linked allotypic determinants on T cells. No genetic restriction was found in its action on allogeneic T cells. The production of IL 2 in proliferative T cells by antigenic stimulation was not inhibited by TsF. These results indicate that the TsF described here is the legitimate mediator produced by the effector-type suppressor T cell that suppresses the antigen-specific responses of Lyt-1+2- T cells. The m.w. of TsF was approximately 75,000.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hemocyanin,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosorbents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor Factors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/keyhole-limpet hemocyanin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
133
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1371-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6205081-Animals,
pubmed-meshheading:6205081-Antigens, Ly,
pubmed-meshheading:6205081-Cell Line,
pubmed-meshheading:6205081-Clone Cells,
pubmed-meshheading:6205081-Epitopes,
pubmed-meshheading:6205081-H-2 Antigens,
pubmed-meshheading:6205081-Hemocyanin,
pubmed-meshheading:6205081-Immunosorbents,
pubmed-meshheading:6205081-Interleukin-2,
pubmed-meshheading:6205081-Lymphocyte Activation,
pubmed-meshheading:6205081-Lymphokines,
pubmed-meshheading:6205081-Mice,
pubmed-meshheading:6205081-Mice, Inbred BALB C,
pubmed-meshheading:6205081-Mice, Inbred C3H,
pubmed-meshheading:6205081-Mice, Inbred C57BL,
pubmed-meshheading:6205081-Molecular Weight,
pubmed-meshheading:6205081-Rats,
pubmed-meshheading:6205081-Rats, Inbred Strains,
pubmed-meshheading:6205081-Suppressor Factors, Immunologic,
pubmed-meshheading:6205081-T-Lymphocytes
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Characterization of an antigen-specific suppressive factor derived from a cloned suppressor effector T cell line.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
