Linked Life Data

6204945

Source:http://linkedlifedata.com/resource/pubmed/id/6204945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-9-7
pubmed:abstractText
The present study has shown that in vitro antibody-dependent cellular cytotoxicity and natural cytotoxicity of human blood lymphocytes are inhibited by retinoic acid (5 X 10(-4)M). The inhibition of cytotoxicity is due to a specific effect on the effector lymphocytes and not to an effect on the target cells. The reduction of killing is most pronounced with prolonged incubation (20 h) of the killer cells with retinoic acid, recovery of killer and natural killer cell activity occurring with post-treatment incubation (greater than 24 h, 37 degrees C) in medium. Retinoic acid was found to have an antagonistic effect to interferon in modulating in vitro natural killer cell activity. The mechanism of inhibition by retinoic acid was uncertain but modulation of cell membrane receptors appeared to be a likely possibility.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Inhibition of antibody-dependent cellular cytotoxicity and natural cytotoxicity by retinoic acid.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't