Linked Life Data

6204483

Source:http://linkedlifedata.com/resource/pubmed/id/6204483

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-8-23
pubmed:abstractText
Analysis of the presence of psoriasis in all first-degree relatives of psoriatic twin probands, 38 monozygotic (MZ) and 24 dizygotic (DZ), has been performed in order to clarify if genetic heterogeneity might be present (the twin-family method). The probands were derived from a population based sample of like-sexed twin pairs. An almost identical frequency of psoriasis in parents, siblings and children, with no sex difference, was found. By comparisons of empirical risk figures for psoriasis in first-degree relatives of concordant as compared with discordant MZ probands and HLA-B 13 and/or HLA-B 17 positive MZ probands compared with MZ probands lacking these antigens, no clue to the presence of genetic heterogeneity was found. An almost identical risk in co-twins and ordinary siblings of DZ-probands was found. The data were incompatible with autosomal recessive or X-linked inheritance, but not incompatible with autosomal dominant inheritance with reduced penetrance or with multifactorial inheritance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5555
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Psoriasis in first-degree relatives of psoriatic twins.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't