| pubmed-article:6203910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0733755 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C1158830 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0041525 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:6203910 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:6203910 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:6203910 | pubmed:dateCreated | 1984-8-20 | lld:pubmed |
| pubmed-article:6203910 | pubmed:abstractText | We have analyzed the requirements for human U1 RNA transcription catalyzed by RNA polymerase II. In Xenopus laevis oocytes, a human U1 RNA gene with only 231 and 35 nucleotides of the 5' and 3' flanking regions, respectively (Lund, E. and Dahlberg, J. E. (1984) J. Biol. Chem. 259, 2013-2021), is able to support accumulation of human U1 RNA. We show that the point in the template corresponding to the 5' end of U1 RNA is a site of transcription initiation. That result rules out the possibility that the 5' end of U1 RNA is generated by cleavage and capping of a precursor RNA. The accumulation of correctly initiated human U1 RNA transcripts requires at least two essential upstream elements. The region between positions -231 and -203 is indispensable for transcription both in oocytes and in vitro. The other region, between positions -105 and -6, fixes the location of the 5' ends of the U1 RNA transcripts in oocytes while not altering the overall level of transcription. This latter region contains a sequence located around position -50, which we propose serves as the analog of the T-A-T-A sequence in U1 and U2 RNA genes. | lld:pubmed |
| pubmed-article:6203910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6203910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6203910 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6203910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6203910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6203910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6203910 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6203910 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:6203910 | pubmed:author | pubmed-author:LundEE | lld:pubmed |
| pubmed-article:6203910 | pubmed:author | pubmed-author:DahlbergJ EJE | lld:pubmed |
| pubmed-article:6203910 | pubmed:author | pubmed-author:MurphyJ TJT | lld:pubmed |
| pubmed-article:6203910 | pubmed:author | pubmed-author:BurgessR RRR | lld:pubmed |
| pubmed-article:6203910 | pubmed:author | pubmed-author:SteinbergT... | lld:pubmed |
| pubmed-article:6203910 | pubmed:author | pubmed-author:SkuzeskiJ MJM | lld:pubmed |
| pubmed-article:6203910 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6203910 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:6203910 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:6203910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6203910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6203910 | pubmed:pagination | 8345-52 | lld:pubmed |
| pubmed-article:6203910 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6203910 | pubmed:meshHeading | pubmed-meshheading:6203910-... | lld:pubmed |
| pubmed-article:6203910 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6203910 | pubmed:articleTitle | Synthesis of human U1 RNA. II. Identification of two regions of the promoter essential for transcription initiation at position +1. | lld:pubmed |
| pubmed-article:6203910 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6203910 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6203910 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6203910 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:6203910 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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