Linked Life Data

6203603

Source:http://linkedlifedata.com/resource/pubmed/id/6203603

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-8-7
pubmed:abstractText
The effects of capsaicin on the crayfish giant axon were examined by using microelectrode and double sucrose gap-voltage clamp methods. Capsaicin (1-3 X 10(-4) M), when applied externally, had no effect on the resting membrane potential but gradually suppressed the action potential. The rate of rise of the action potential was simultaneously decreased. Voltage clamp experiments revealed the following: capsaicin (10(-4) M) reduced more effectively the transient sodium current than the steady-state potassium current. Inhibition of the sodium current was derived from a decrease in maximum sodium conductance, as the equilibrium potential remained much the same. The inhibitory effects of capsaicin on action potentials and membrane ionic currents were slowly reversible after removal of capsaicin. These results indicate that capsaicin seems to produce a conduction block in the crayfish giant axon due to an inhibition of sodium channels. The significance of these findings is discussed in relation to the sensory neurone-blocking action of capsaicin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
300
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Conduction-block induced by capsaicin in crayfish giant axon.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't