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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3-4
|
pubmed:dateCreated |
1984-7-25
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pubmed:abstractText |
Both cyclic and linear somatostatin-14 are potent histamine secretagogues in rat mast cell incubates. Linear somatostatin-14 is more effective than cyclic somatostatin-14 in a concentration range up to 10(-6) mol/l, in normal Sprague-Dawley rats, and even more responsive in sensitized hooded Lister rats. This additional mast cell stimulation capacity of linear somatostatin-14 depends on circulating IgE levels. No differences are observed in athymic rat mast cell incubates between the linear and the cyclic isomer of somatostatin-14. A direct unspecific interaction of linear somatostatin with cell surface antibodies can be concluded.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0065-4299
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
506-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6203374-Animals,
pubmed-meshheading:6203374-DiGeorge Syndrome,
pubmed-meshheading:6203374-Dose-Response Relationship, Drug,
pubmed-meshheading:6203374-Histamine Release,
pubmed-meshheading:6203374-Immunoglobulin E,
pubmed-meshheading:6203374-Immunologic Deficiency Syndromes,
pubmed-meshheading:6203374-Male,
pubmed-meshheading:6203374-Mast Cells,
pubmed-meshheading:6203374-Rats,
pubmed-meshheading:6203374-Rats, Inbred Strains,
pubmed-meshheading:6203374-Somatostatin
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pubmed:year |
1984
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pubmed:articleTitle |
Somatostatin-induced histamine release in mast cell incubates from thymusaplastic nude rats.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|