| pubmed-article:6202819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0032131 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:6202819 | lifeskim:mentions | umls-concept:C0071986 | lld:lifeskim |
| pubmed-article:6202819 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6202819 | pubmed:dateCreated | 1984-7-13 | lld:pubmed |
| pubmed-article:6202819 | pubmed:abstractText | Plasmacytomas with short latent periods can be induced in BALB/c mice by a single intraperitoneal (i.p.) injection of 0.5 ml pristane followed 20-40 d later by an injection of Abelson virus. The karyotypes of 18 such tumors were determined; 10 of these had rcpt 12;15, 5 had rcpt 6;15 and 3 had no translocations, but two of these have been shown to have interstitial deletions of chromosome 15. The specific breakpoints were the same as described in pristane-induced plasmacytomas, i.e., at 15D2 /3, 6C2 , and 12F2 . Near diploid karyotypes and trisomy of chromosome 11 were frequently seen. All of the Abelson-plus-pristane-induced plasmacytomas (ABPC) were studied as transplanted tumors, contained integrated v- abl sequences, and actively transcribed v- abl mRNA. All but one of these tumors contained abundant myc RNA transcripts. The shortness of the latent periods of the ABPC suggests that the rcpt 12;15 and rcpt 6;15 occur soon after pristane administration and are present at the time Abelson virus is introduced. In this form of plasmacytomagenesis , activated v- abl genes appear to bypass other genetic changes that require a much longer period of time in pristane plasmacytomagenesis . Nonetheless, the consistent finding of chromosome-15 alterations and abundant myc expression in these plasmacytomas emphasize the apparent need for multiple events even in the genesis of some tumors induced by rapid transforming viruses. | lld:pubmed |
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| pubmed-article:6202819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6202819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6202819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6202819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6202819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6202819 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6202819 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:KleinGG | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:OhnoSS | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:PotterMM | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:MigitaSS | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:WienerFF | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:MushinskiJ... | lld:pubmed |
| pubmed-article:6202819 | pubmed:author | pubmed-author:BabonitsMM | lld:pubmed |
| pubmed-article:6202819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6202819 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6202819 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:6202819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6202819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6202819 | pubmed:pagination | 1762-77 | lld:pubmed |
| pubmed-article:6202819 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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