Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-7-13
pubmed:abstractText
Plasmacytomas with short latent periods can be induced in BALB/c mice by a single intraperitoneal (i.p.) injection of 0.5 ml pristane followed 20-40 d later by an injection of Abelson virus. The karyotypes of 18 such tumors were determined; 10 of these had rcpt 12;15, 5 had rcpt 6;15 and 3 had no translocations, but two of these have been shown to have interstitial deletions of chromosome 15. The specific breakpoints were the same as described in pristane-induced plasmacytomas, i.e., at 15D2 /3, 6C2 , and 12F2 . Near diploid karyotypes and trisomy of chromosome 11 were frequently seen. All of the Abelson-plus-pristane-induced plasmacytomas (ABPC) were studied as transplanted tumors, contained integrated v- abl sequences, and actively transcribed v- abl mRNA. All but one of these tumors contained abundant myc RNA transcripts. The shortness of the latent periods of the ABPC suggests that the rcpt 12;15 and rcpt 6;15 occur soon after pristane administration and are present at the time Abelson virus is introduced. In this form of plasmacytomagenesis , activated v- abl genes appear to bypass other genetic changes that require a much longer period of time in pristane plasmacytomagenesis . Nonetheless, the consistent finding of chromosome-15 alterations and abundant myc expression in these plasmacytomas emphasize the apparent need for multiple events even in the genesis of some tumors induced by rapid transforming viruses.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-1003103, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-14207859, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-14768711, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-4109406, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-4120886, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-4318922, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-4355680, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-519762, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-5789334, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6188153, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6253808, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6258798, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6264461, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6276760, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-628020, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6285962, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6287020, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6287471, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6288259, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6292737, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6294668, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6302668, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6303705, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6304522, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6304686, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6308472, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6308473, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6316149, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6356358, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6401867, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6402776, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6422467, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6572957, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6576197, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6600817, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6646229, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6687762, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6772444, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6819085, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-686360, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6959142, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-6960358, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-702054, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-7146913, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-7307580, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-7444720, http://linkedlifedata.com/resource/pubmed/commentcorrection/6202819-881736
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
159
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1762-77
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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