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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1984-5-30
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|
pubmed:abstractText |
A regimen of high-dose methotrexate with leucovorin rescue, vinblastine, and bleomycin with or without tamoxifen was administered to 34 patients with metastatic renal cell carcinoma. No complete remissions were observed, but ten patients (30%) achieved partial remission and an additional 13 patients (39%) had stabilization of disease. The median survival of responding patients (110 weeks) was significantly longer than that of nonresponding patients. The addition of tamoxifen did not influence response or survival. This regimen was tolerated without significant toxicity. A prospective randomized study of the vinblastine and high-dose methotrexate regimen compared to the respective single agents seem to be indicated.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0361-5960
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
68
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
587-90
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|
pubmed:dateRevised |
2006-4-24
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|
pubmed:meshHeading |
pubmed-meshheading:6201268-Adenocarcinoma,
pubmed-meshheading:6201268-Adult,
pubmed-meshheading:6201268-Aged,
pubmed-meshheading:6201268-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:6201268-Bleomycin,
pubmed-meshheading:6201268-Drug Evaluation,
pubmed-meshheading:6201268-Female,
pubmed-meshheading:6201268-Hematologic Diseases,
pubmed-meshheading:6201268-Humans,
pubmed-meshheading:6201268-Kidney Neoplasms,
pubmed-meshheading:6201268-Leucovorin,
pubmed-meshheading:6201268-Male,
pubmed-meshheading:6201268-Methotrexate,
pubmed-meshheading:6201268-Middle Aged,
pubmed-meshheading:6201268-Neoplasm Metastasis,
pubmed-meshheading:6201268-Random Allocation,
pubmed-meshheading:6201268-Tamoxifen,
pubmed-meshheading:6201268-Time Factors,
pubmed-meshheading:6201268-Vinblastine
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|
pubmed:year |
1984
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|
pubmed:articleTitle |
High-dose methotrexate with leucovorin rescue, vinblastine, and bleomycin with or without tamoxifen in metastatic renal cell carcinoma.
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pubmed:publicationType |
Journal Article
|
