rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1984-5-11
|
pubmed:abstractText |
Translation products in Xenopus laevis of mRNA from human peripheral blood mononuclear cells were tested for their capacity to replace T cells in the anti-SRBC response of nude spleen cells. When the starting material came from PHA or FCS-stimulated lymphocytes, the translated lymphokines, displaying such a B cell helper activity were found to be encoded by mRNA sedimenting at 6-7S and 13S on a sucrose density gradient. 6-7S mRNA from control, non-stimulated lymphocytes was also able to code for B cell helper activity. Thorough T-cell depletion of mouse responder cell populations left unchanged the activity of 6-7S mRNA products while preventing that of 13S products. The latter were found to contain IL-2, which suggests that their action on B cells was indirect, mediated by T-cell stimulation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
119
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
868-75
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6201168-Animals,
pubmed-meshheading:6201168-Antibodies,
pubmed-meshheading:6201168-Antibody Formation,
pubmed-meshheading:6201168-Female,
pubmed-meshheading:6201168-Humans,
pubmed-meshheading:6201168-Interleukin-2,
pubmed-meshheading:6201168-Lymphoma,
pubmed-meshheading:6201168-Mice,
pubmed-meshheading:6201168-Mice, Inbred Strains,
pubmed-meshheading:6201168-Mice, Nude,
pubmed-meshheading:6201168-Oocytes,
pubmed-meshheading:6201168-Poly A,
pubmed-meshheading:6201168-RNA,
pubmed-meshheading:6201168-RNA, Messenger,
pubmed-meshheading:6201168-T-Lymphocytes,
pubmed-meshheading:6201168-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6201168-Xenopus
|
pubmed:year |
1984
|
pubmed:articleTitle |
Helper activity for antibody synthesis encoded by mRNA extracted from human peripheral blood mononuclear cells.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|