Linked Life Data

6201128

Source:http://linkedlifedata.com/resource/pubmed/id/6201128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-5-24
pubmed:abstractText
Phosphocholine-specific antibodies in mice are composed of three families of antibodies, the T15, the M603 and the M511, which are constructed by combinatorial association of a VH4 H chain and one of three different L chains, VK22, VK8 and VK24, respectively. Antiidiotypic antisera can be generated which (1) recognize all members of a family, i. e. anti-T15 IdX, anti-M603 IdX and anti-M511 IdX, (2) distinguish between members of a family, e. g. A/J anti-T15, or (3) recognize determinants on only a single anti-PC antibody. Consideration of protein sequences and L-chain polymorphisms and analysis of chain recombination experiments among Id-positive and -negative antibodies revealed that IdX are determined by the L chain. A similar approach demonstrated that the Id determinant defined by the A/J anti-T15 is dependent upon the L chain and the D region of the H chain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-4910
pubmed:author
pubmed:issnType
Print
pubmed:volume
135C
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-22
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Idiotypes of anti-phosphocholine antibodies: structural correlates.
pubmed:publicationType
Journal Article