Linked Life Data

6201003

Source:http://linkedlifedata.com/resource/pubmed/id/6201003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-5-14
pubmed:abstractText
Adult rats were examined for the time course of inactivation of antigenic determinants of tritium-labeled bovine serum albumin (BSA) or chicken ovalbumin administered intragastrically. Immunoreactive protein in the perfusates was determined according to the amount of the radioactive label retained by the immunosorbent. Antigenic determinants of protein disintegrated very rapidly after protein penetrated the gastrointestinal tract. Within 20 minutes after administration their amount did not exceed 12% of the dose administered. BSA disintegrated more rapidly than ovalbumin. At the same time after 20, 60 and 180 min an insignificant amount (about 1%) of immunoreactive protein penetrated the distal part of the small and large intestines. The amount of high-molecular fragments in all the parts of the gastrointestinal tract exceeded the discovered amount of immunoreactive protein. The data obtained indicate that a small amount of foreign food antigens is capable of overcoming the barrier of the cavitary proteolysis and of reaching those parts of the intestine where they can be absorbed in the intact form.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-8833
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-51
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
[Breakdown of dietary proteins in the gastrointestinal tract of the adult rat].
pubmed:publicationType
Journal Article, English Abstract