Linked Life Data

6200055

Source:http://linkedlifedata.com/resource/pubmed/id/6200055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-4-4
pubmed:abstractText
Lymphocyte cultures were treated with bleomycin to see if individuals who exhibit a high rate of spontaneous chromosome breakage also show an exaggerated response to clastogenic agents. For our experimental group, we used patients with medullary thyroid carcinoma and their immediate family members. Lymphocytes from these individuals tend to show high rates of spontaneous chromosome breakage. The average bleomycin-induced breakage rate in this group was significantly higher than that found in the normal controls. In the control group, the distribution of breakage rates was bimodal, with mean values of 0.68 breaks per cell in one group, and 1.84 breaks/cell in the other. The high rate of induced breakage shown by phenotypically normal subjects may mean that these individuals have a potential sensitivity to mutagen exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Bleomycin-induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't