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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1984-4-17
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pubmed:abstractText |
The neuropeptides, substance P, vasoactive intestinal peptide (VIP), neuropeptide Y and enkephalin have been found in nerves associated with the heart and blood vessels of a range of mammals, including man. There is also evidence for some cardiovascular nerves with gastrin releasing peptide and neurotensin immunoreactivity. Substance P is in sensory nerves with a widespread distribution to the heart and all vascular beds. In general, large arteries have the densest innervation and the density of nerves decreases as arterial size decreases. In adult guinea-pigs, an adequate treatment with capsaicin causes the degeneration of almost all cardiovascular substance P nerves. Using capsaicin as a tool it has been shown that the substance P containing sensory nerves are not essential for baroreceptor reflexes. VIP nerves also have a widespread distribution, being particularly prominent in the cerebral arteries, uterine arteries and arteries of erectile and secretory tissues. Neuropeptide Y is located in the same cardiovascular nerves as noradrenaline. It is depleted from the nerves by reserpine or 6-hydroxydopamine. Enkephalin nerves have been reported with small arteries in only a few vascular beds.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrin-Releasing Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide
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pubmed:status |
MEDLINE
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pubmed:issn |
0730-0077
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-106
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pubmed:dateRevised |
2008-2-12
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pubmed:meshHeading |
pubmed-meshheading:6199137-Animals,
pubmed-meshheading:6199137-Capsaicin,
pubmed-meshheading:6199137-Cardiovascular System,
pubmed-meshheading:6199137-Enkephalins,
pubmed-meshheading:6199137-Gastrin-Releasing Peptide,
pubmed-meshheading:6199137-Humans,
pubmed-meshheading:6199137-Nerve Tissue Proteins,
pubmed-meshheading:6199137-Neuropeptide Y,
pubmed-meshheading:6199137-Peptides,
pubmed-meshheading:6199137-Peripheral Nerves,
pubmed-meshheading:6199137-Substance P,
pubmed-meshheading:6199137-Vasoactive Intestinal Peptide
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pubmed:year |
1984
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pubmed:articleTitle |
Neuropeptides contained in peripheral cardiovascular nerves.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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