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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-4-24
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pubmed:abstractText |
The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
294
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
174-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6199090-Animals,
pubmed-meshheading:6199090-Behavior, Animal,
pubmed-meshheading:6199090-Brain,
pubmed-meshheading:6199090-Cyclazocine,
pubmed-meshheading:6199090-Hydromorphone,
pubmed-meshheading:6199090-Ketamine,
pubmed-meshheading:6199090-Male,
pubmed-meshheading:6199090-Phenazocine,
pubmed-meshheading:6199090-Phencyclidine,
pubmed-meshheading:6199090-Rats,
pubmed-meshheading:6199090-Rats, Inbred Strains,
pubmed-meshheading:6199090-Receptors, Opioid,
pubmed-meshheading:6199090-Stereoisomerism
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pubmed:year |
1984
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pubmed:articleTitle |
Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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