Linked Life Data

6198662

Source:http://linkedlifedata.com/resource/pubmed/id/6198662

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-3-21
pubmed:abstractText
Nucleoside analog were used to stimulate fetal hemoglobin synthesis in baboons. Only those nucleoside analogs (5-azacytidine and 2'-deoxy-5-azacytidine) that blocked DNA methylation caused large increases in Hb F levels. DNA extracted from bone marrow samples of these animals was cleaved with MspI or HpaII restriction enzymes and analyzed by Southern blot hybridization. Results of these experiments strongly support the hypothesis that hypomethylation of CCGG sequences in the gamma-gene region is a condition of gamma-gene expression. This also applies to Hb F elevations resulting from erythropoietic stress due to phenylhydrazine-induced hemolytic anemia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-500
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Fetal hemoglobin production in adult baboons by 5-azacytidine or by phenylhydrazine-induced hemolysis is associated with hypomethylation of globin gene DNA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't