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rdf:type |
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lifeskim:mentions |
umls-concept:C0023693,
umls-concept:C0024554,
umls-concept:C0031939,
umls-concept:C0033991,
umls-concept:C0034716,
umls-concept:C0043157,
umls-concept:C0220781,
umls-concept:C0220938,
umls-concept:C0332157,
umls-concept:C0332182,
umls-concept:C0332583,
umls-concept:C1453201,
umls-concept:C1883254
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pubmed:issue |
1-2
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pubmed:dateCreated |
1984-2-15
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pubmed:abstractText |
The pineals of 28 days old male Wistar rats, in December periodically exposed to either white or green light, were incubated with pterin-6-aldehyde or reduced neopterin. In white light the rhythm of synthesis of 5-methoxytryptophan and of 5-methoxyindole-3-acetic acid was clearly influenced by the pteridines mentioned. In green light a change in rhythmicity of 5-methoxytryptophan, 5-methoxytryptamine and of melatonin/5-methoxytryptophol synthesis by the pteridines was observed. In white light both pteridines increased 5-methoxytryptophan and decreased 5-methoxyindole-3-acetic acid synthesis. Reduced neopterin stimulated 5-methoxytryptamine synthesis and inhibited melatonin/5-methoxytryptophol synthesis. Pterin-6-aldehyde showed an opposite effect. In green light both pteridines decreased 5-methoxytryptophan synthesis, but increased 5-methoxyindole-3-acetic acid and 5-methoxytryptamine synthesis. Melatonin/5-methoxytryptophol synthesis was decreased by reduced neopterin and increased by pterin-6-aldehyde. The results suggest an indolic metabolic pathway leading from 5-methoxytryptophan via 5-methoxytryptamine to melatonin, while pteridines and light of different wave lengths are correlated in regulating indole metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-4-hydroxy-6-formylpteridine,
http://linkedlifedata.com/resource/pubmed/chemical/5-Methoxytryptamine,
http://linkedlifedata.com/resource/pubmed/chemical/5-methoxyindoleacetic acid,
http://linkedlifedata.com/resource/pubmed/chemical/5-methoxytryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/Biopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyindoleacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Melanins,
http://linkedlifedata.com/resource/pubmed/chemical/Neopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Pteridines,
http://linkedlifedata.com/resource/pubmed/chemical/Pterins,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/methoxytryptophol
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-9564
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-34
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6197508-5-Methoxytryptamine,
pubmed-meshheading:6197508-Animals,
pubmed-meshheading:6197508-Biopterin,
pubmed-meshheading:6197508-Hydroxyindoleacetic Acid,
pubmed-meshheading:6197508-Indoles,
pubmed-meshheading:6197508-Light,
pubmed-meshheading:6197508-Male,
pubmed-meshheading:6197508-Melanins,
pubmed-meshheading:6197508-Neopterin,
pubmed-meshheading:6197508-Pineal Gland,
pubmed-meshheading:6197508-Pteridines,
pubmed-meshheading:6197508-Pterins,
pubmed-meshheading:6197508-Rats,
pubmed-meshheading:6197508-Rats, Inbred Strains,
pubmed-meshheading:6197508-Tryptophan
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pubmed:year |
1983
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pubmed:articleTitle |
The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light.
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pubmed:publicationType |
Journal Article
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