Linked Life Data

6197446

Source:http://linkedlifedata.com/resource/pubmed/id/6197446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-14
pubmed:abstractText
By using a hemolytic plaque assay for IFN-gamma secretion by single cells, we found that one to three IFN-gamma secreting cells per 1 X 10(3) mononuclear cells were present in the blood from normal adult and newborn humans, without in vitro culture or stimulation by antigens or mitogens. The frequency of such cells was higher in newborns. These spontaneous IFN-gamma-secreting cells were predominantly T cells of the helper/inducer phenotype, as defined by treatment with monoclonal antibody and complement. By using indirect immunofluorescence staining, it was seen that 1% of blood mononuclear cells from adults and 3.5% from newborns contained cytoplasmic IFN-gamma. These cytoplasmic IFN-gamma-positive cells belonged to a heterogeneous population by morphology and by staining with monoclonal antibody. The majority of these cells were DR-positive T cells. We propose that these IFN-gamma-producing cells were activated in vivo, and that they possibly mediate antiviral or lymphokine activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Spontaneous production of interferon-gamma in adult and newborn humans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't