rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1984-2-24
|
pubmed:abstractText |
This study of the effect of high-dose intravenous gammaglobulins with one or two courses of therapy in 18 adults with idiopathic thrombocytopenia purpura showed a platelet rise in thirteen patients. The highest response rates were seen in splenectomized adults. In chronic patients the response was transient only. If therapy was effective, increased values of platelet-associated IgG were reduced, while shortened platelet survival times were prolonged. There was no influence of high-dose gammaglobulins on platelet function. different 7S-preparations such as beta-propiolactone modified Ig, pH 4 treated Ig and reduced and alkylated Ig have comparable effects.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0006-5242
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
48
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
19-25
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6197117-Adolescent,
pubmed-meshheading:6197117-Adult,
pubmed-meshheading:6197117-Aged,
pubmed-meshheading:6197117-Blood Coagulation Tests,
pubmed-meshheading:6197117-Cell Survival,
pubmed-meshheading:6197117-Dose-Response Relationship, Drug,
pubmed-meshheading:6197117-Female,
pubmed-meshheading:6197117-Half-Life,
pubmed-meshheading:6197117-Humans,
pubmed-meshheading:6197117-Male,
pubmed-meshheading:6197117-Middle Aged,
pubmed-meshheading:6197117-Platelet Aggregation,
pubmed-meshheading:6197117-Platelet Count,
pubmed-meshheading:6197117-Propiolactone,
pubmed-meshheading:6197117-Purpura, Thrombocytopenic,
pubmed-meshheading:6197117-Splenectomy,
pubmed-meshheading:6197117-gamma-Globulins
|
pubmed:year |
1984
|
pubmed:articleTitle |
High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP). Clinical effects.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|